TSO/ISPF Fundamentals
Understand TSO as the interactive time-sharing interface to z/OS and ISPF as the panel-driven productivity layer built on top of it.
TSO (Time Sharing Option) is z/OS's interactive login environment, and ISPF (Interactive System Productivity Facility) is the menu-and-panel-driven application most mainframe developers actually live in day to day — editing source, browsing datasets, submitting jobs, and checking output. Every mainframe developer interview assumes baseline comfort here, because it's simply how the daily work of writing and testing code happens.
TSO is the phone line connecting you to the mainframe; ISPF is the numbered voicemail menu system built on top of that line that gets you to exactly the function you need (press 2 for editing, 3 for dataset utilities) without having to dial a raw, unstructured command every time.